Publications
Research Papers/Preprints/Primers (co-first authors are underlined)
Chen YJ, Wu SJ, Tang YC, Wu YC, Chiang YC, Pan CL.* Transcriptome and mutant analysis of neuronal genes for memory formation and retrieval in Caenorhabditis elegans. bioRxiv [link]
Tsai SH, Wu YC, Palomino DF, Schroeder FC, Pan CL*. (2024) Peripheral peroxisomal beta-oxidation engages neuronal serotonin to drive stress-induced aversive memory in C. elegans. Cell Reports 43: 113996. [link]
Chen YJ and Pan CL*. (2023) An olfactory-interneuron circuit that drives stress-induced avoidance behavior in C. elegans. Neuroscience Research 191: 91-97. [link]
Liao CP, Chiang YC, Tam WH, Chen YJ, Chou SH, Pan CL*. (2022) Neurophysiological basis of stress-induced aversive memory in the nematode Caenorhabditis elegans. Current Biology 34; DOI: https://doi.org/10.1016/j.cub.2022.11.012 [link]
Pan CL. (2022) May the force be with you: mechanosensitivity shapes dendrite development. Developmental Cell 57: P1561-1562.
Chiang YC, Liao CP, Pan CL*. (2022) A serotonergic circuit regulates aversive associative learning under mitochondrial stress in C. elegans. Proc. Natl. Acad. Sci. USA. 119(11) e2115533119 [link]
Chou SH, Chen YJ, Liao CP, Pan CL*. (2022) A role for dopamine in C. elegans avoidance behavior induced by mitochondrial stress. Neuroscience Research 178: 87-92. [link]
Chen LT, Lin CT, Lin LY, Hsu JM, Wu YC, Pan CL.* (2021) Neuronal mitochondrial dynamics coordinate systemic mitochondrial morphology and stress response to confer pathogen resistance in C. elegans. Developmental Cell 56: 1770-1785 (Highlighted in Nature Reviews Neuroscience) [link]
Hsu HW, Liao CP, Chiang YC, Syu RT, Pan CL*. (2020) C. elegans flamingo FMI-1 controls dendrite self-avoidance through F-actin assembly. Development 147(14):dev179168. doi:10.1242/dev.179168. [link]
Huang TT, Matsuyama H, Tsukada Y, Singhvi A, Syu RT, Lu Y, Shaham S, Mori I*, Pan CL*. (2020) Age-dependent changes in response property and morphology of a thermosensory neuron and thermotaxis behavior in Caenorhabditis elegans. Aging Cell 19(5): e13146. DOI:10.1111/acel.13146 (* co-correspondence) [link]
Chen CH, Hsu HW, Chang YH, Pan CL*. (2019) Adhesive L1CAM-Robo signaling aligns growth cone F-actin dynamics to promote axon-dendrite fasciculation in C. elegans. Developmental Cell 48: 215-228. (recommended by FB1000) [link]
He CW, Liao CP, Chen CK, Teuliere J, Chen CH, Pan CL*. (2018). The polarity protein VANG-1 antagonizes Wnt signaling by facilitating Frizzled endocytosis. Development 145: dev168666. [link]
Liao CP, Li H, Lee HH, Chien CT, Pan CL*. (2018) Cell-autonomous regulation of dendrite self-avoidance by the Wnt secretory factor MIG-14/Wntless. Neuron 98: 320-334 (highlighted in the same issue). [link]
Chen CH, He CW, Liao CP, Pan CL*. (2017) A Wnt-planar polarity pathway instructs neurite branching by restricting F-actin assembly through Endosomal Signaling. PLOS Genet 13: e1006720 [link]
Chen YC, Chen HJ, Tseng WC, Hsu JM, Huang TT, Chen CH, Pan CL*. (2016). A C. elegans thermosensory circuit regulates longevity through crh-1/CREB-dependent flp-6 neuropeptide signaling. Developmental Cell 39: 209-223. (highlighted in Developmental Cell and Science Signaling) [link]
Jiang HC, Hsu, JM, Yen CP, Chao CC, Chen RH, Pan CL*. (2015). Neural activity and CaMKII protect mitochondria from fragmentation in aging C. elegans neurons. Proc. Natl. Acad. Sci. USA. 112: 8768-8773 [link]
Chen CH, Lee A, Liao CP, Liu YW, Pan CL*. (2014). RHGF-1/PDZ-RhoGEF and retrograde DLK-1 signaling drive neuronal remodeling on microtubule disassembly. Proc. Natl. Acad. Sci. USA. 111: 16568-16573 [link]
Hsu JM, Chen CH, Chen YC, McDonald KL, Gurling M, Lee A, Garriga G, Pan CL*. (2014). Genetic analysis of a novel tubulin mutation that redirects synaptic vesicle targeting and causes neurite degeneration in C. elegans. PLOS Genet. 10: e1004715 [link]
Pan CL*, Peng CY, Chen CH, McIntire SL*. (2011). Genetic analysis of age-dependent defects of C. elegans touch receptor neurons. Proc. Natl. Acad. Sci. USA. 108: 9274-9279 (recommended by FB1000) [link]
Pan CL, and Garriga G. (2008). Fresh air is good for nerves: hypoxia disturbs axon guidance. Nat. Neurosci. 11: 859-861. [link]
Pan CL, Baum PD, Gu M, Jorgensen EM, Clark SG, Garriga G. (2008). C. elegans AP-2 and retromer control Wnt secretion by regulating MIG-14/Wntless. Developmental Cell 14: 132-139 (highlighted in Dev. Cell 14: 4-6 and Nat. Rev. Mol. Cell Biol. 2008; 9(2)) [link]
Pan CL, Howell JE, Clark SG, Hilliard MA, Cordes S, Bargmann CI, Garriga G. (2006). Multiple Wnts and Frizzled receptors regulate anteriorly directed cell and growth cone migrations in Caenorhabditis elegans. Developmental Cell 10: 367-377 (highlighted in Neuron 2006; 49: 787-789; recommended by FB1000) [link]
Tseng MT, Hsieh SC, Shun CT, Lee KL, Pan CL, Lin WM, Lin YH, Yu CL, Hsieh ST. (2006). Skin denervation and cutaneous vasculitis in systemic lupus erythematosus. Brain 129: 977-985. [link]
Pan CL, Kuo MF, Hsieh ST. (2004). Auditory agnosia caused by a tectal germinoma. Neurology 63: 2387-2389. [link]
Pan CL, Shun CT, Susuki K, Yuki N, Hsieh ST. (2004). Pharyngeal-brachial palsy after cytomegalovirus colitis. Neurology 62:153-154 (highlight article)
Pan CL, Tseng TJ, Lin YH, Chiang MC, Lin WM, Hsieh ST. (2003). Cutaneous innervation in Guillain-Barré syndrome: pathology and clinical correlations. Brain 126:386-397. [link]
Chiang MC, Lin YH, Pan CL, Tseng TJ, Lin WM, Hsieh ST. (2002). Cutaneous innervation in chronic inflammatory demyelinating polyneuropathy. Neurology 59: 1094-1098. [link]
Pan CL, Yuki N, Koga M, Chiang MC, Hsieh ST. (2001). Acute sensory ataxic neuropathy associated with monospecific anti-GD1b IgG antibody. Neurology 57: 1316-1318. [link]
Pan CL, Lin YH, Lin WM, Tai TY, Hsieh ST. (2001). Degeneration of nociceptive nerve terminals in human peripheral neuropathy. Neuroreport 12: 787-792. [link]
Reviews, Commentaries and Methods Papers
Chen CK and Pan CL.* (2022) Cell polarity control by Wnt morphogens. Developmental Biology 487: 34-41.
Chen CH* and Pan CL.* (2021) Live-cell imaging of PVD dendrite growth cone in post-embryonic C. elegans. STAR Protocols 2: 100402 [link]
Wu YC, Chiang YC, Chou SH, Pan CL. (2021) Wnt signaling and endocytosis: mechanisms, controversies and implications for stress responses (invited review). Biol Cell 113: 95-106. doi:10.1111/boc.202000099 online ahead of print [link]
He CW, Liao CP, Pan CL. (2018) Wnt signaling in the development of axon, dendrites and synapses (invited review). Open Biology (Royal Society of UK) 8: 180116. [link]
Lin CT, He CW, Huang TT, Pan CL. (2017) Longevity control by the nervous system: sensory perception, stress response and beyond. (invited review) Transl. Med. Aging 1: 41-51 [link]
Chiang MC, Tseng MT, Pan CL, Chao CC, Hsieh ST. (2015). Progress in the treatment of small fiber peripheral neuropathy. Expert Rev. Neurother. 15: 305-313. [link]
Chen CH, Chen YC, Jiang HC, Chen CK, Pan CL. (2013). Neuronal aging: learning from C. elegans. (invited review) J. Mol. Signal. 8: 14 [link]
Peng CY, Chen CH, Hsu JM, Pan CL. (2011). C. elegans model of neuronal aging. Commun. Integr. Biol. 4: 696-698. [link]
Research Papers/Preprints/Primers (co-first authors are underlined)
Chen YJ, Wu SJ, Tang YC, Wu YC, Chiang YC, Pan CL.* Transcriptome and mutant analysis of neuronal genes for memory formation and retrieval in Caenorhabditis elegans. bioRxiv [link]
Tsai SH, Wu YC, Palomino DF, Schroeder FC, Pan CL*. (2024) Peripheral peroxisomal beta-oxidation engages neuronal serotonin to drive stress-induced aversive memory in C. elegans. Cell Reports 43: 113996. [link]
Chen YJ and Pan CL*. (2023) An olfactory-interneuron circuit that drives stress-induced avoidance behavior in C. elegans. Neuroscience Research 191: 91-97. [link]
Liao CP, Chiang YC, Tam WH, Chen YJ, Chou SH, Pan CL*. (2022) Neurophysiological basis of stress-induced aversive memory in the nematode Caenorhabditis elegans. Current Biology 34; DOI: https://doi.org/10.1016/j.cub.2022.11.012 [link]
Pan CL. (2022) May the force be with you: mechanosensitivity shapes dendrite development. Developmental Cell 57: P1561-1562.
Chiang YC, Liao CP, Pan CL*. (2022) A serotonergic circuit regulates aversive associative learning under mitochondrial stress in C. elegans. Proc. Natl. Acad. Sci. USA. 119(11) e2115533119 [link]
Chou SH, Chen YJ, Liao CP, Pan CL*. (2022) A role for dopamine in C. elegans avoidance behavior induced by mitochondrial stress. Neuroscience Research 178: 87-92. [link]
Chen LT, Lin CT, Lin LY, Hsu JM, Wu YC, Pan CL.* (2021) Neuronal mitochondrial dynamics coordinate systemic mitochondrial morphology and stress response to confer pathogen resistance in C. elegans. Developmental Cell 56: 1770-1785 (Highlighted in Nature Reviews Neuroscience) [link]
Hsu HW, Liao CP, Chiang YC, Syu RT, Pan CL*. (2020) C. elegans flamingo FMI-1 controls dendrite self-avoidance through F-actin assembly. Development 147(14):dev179168. doi:10.1242/dev.179168. [link]
Huang TT, Matsuyama H, Tsukada Y, Singhvi A, Syu RT, Lu Y, Shaham S, Mori I*, Pan CL*. (2020) Age-dependent changes in response property and morphology of a thermosensory neuron and thermotaxis behavior in Caenorhabditis elegans. Aging Cell 19(5): e13146. DOI:10.1111/acel.13146 (* co-correspondence) [link]
Chen CH, Hsu HW, Chang YH, Pan CL*. (2019) Adhesive L1CAM-Robo signaling aligns growth cone F-actin dynamics to promote axon-dendrite fasciculation in C. elegans. Developmental Cell 48: 215-228. (recommended by FB1000) [link]
He CW, Liao CP, Chen CK, Teuliere J, Chen CH, Pan CL*. (2018). The polarity protein VANG-1 antagonizes Wnt signaling by facilitating Frizzled endocytosis. Development 145: dev168666. [link]
Liao CP, Li H, Lee HH, Chien CT, Pan CL*. (2018) Cell-autonomous regulation of dendrite self-avoidance by the Wnt secretory factor MIG-14/Wntless. Neuron 98: 320-334 (highlighted in the same issue). [link]
Chen CH, He CW, Liao CP, Pan CL*. (2017) A Wnt-planar polarity pathway instructs neurite branching by restricting F-actin assembly through Endosomal Signaling. PLOS Genet 13: e1006720 [link]
Chen YC, Chen HJ, Tseng WC, Hsu JM, Huang TT, Chen CH, Pan CL*. (2016). A C. elegans thermosensory circuit regulates longevity through crh-1/CREB-dependent flp-6 neuropeptide signaling. Developmental Cell 39: 209-223. (highlighted in Developmental Cell and Science Signaling) [link]
Jiang HC, Hsu, JM, Yen CP, Chao CC, Chen RH, Pan CL*. (2015). Neural activity and CaMKII protect mitochondria from fragmentation in aging C. elegans neurons. Proc. Natl. Acad. Sci. USA. 112: 8768-8773 [link]
Chen CH, Lee A, Liao CP, Liu YW, Pan CL*. (2014). RHGF-1/PDZ-RhoGEF and retrograde DLK-1 signaling drive neuronal remodeling on microtubule disassembly. Proc. Natl. Acad. Sci. USA. 111: 16568-16573 [link]
Hsu JM, Chen CH, Chen YC, McDonald KL, Gurling M, Lee A, Garriga G, Pan CL*. (2014). Genetic analysis of a novel tubulin mutation that redirects synaptic vesicle targeting and causes neurite degeneration in C. elegans. PLOS Genet. 10: e1004715 [link]
Pan CL*, Peng CY, Chen CH, McIntire SL*. (2011). Genetic analysis of age-dependent defects of C. elegans touch receptor neurons. Proc. Natl. Acad. Sci. USA. 108: 9274-9279 (recommended by FB1000) [link]
Pan CL, and Garriga G. (2008). Fresh air is good for nerves: hypoxia disturbs axon guidance. Nat. Neurosci. 11: 859-861. [link]
Pan CL, Baum PD, Gu M, Jorgensen EM, Clark SG, Garriga G. (2008). C. elegans AP-2 and retromer control Wnt secretion by regulating MIG-14/Wntless. Developmental Cell 14: 132-139 (highlighted in Dev. Cell 14: 4-6 and Nat. Rev. Mol. Cell Biol. 2008; 9(2)) [link]
Pan CL, Howell JE, Clark SG, Hilliard MA, Cordes S, Bargmann CI, Garriga G. (2006). Multiple Wnts and Frizzled receptors regulate anteriorly directed cell and growth cone migrations in Caenorhabditis elegans. Developmental Cell 10: 367-377 (highlighted in Neuron 2006; 49: 787-789; recommended by FB1000) [link]
Tseng MT, Hsieh SC, Shun CT, Lee KL, Pan CL, Lin WM, Lin YH, Yu CL, Hsieh ST. (2006). Skin denervation and cutaneous vasculitis in systemic lupus erythematosus. Brain 129: 977-985. [link]
Pan CL, Kuo MF, Hsieh ST. (2004). Auditory agnosia caused by a tectal germinoma. Neurology 63: 2387-2389. [link]
Pan CL, Shun CT, Susuki K, Yuki N, Hsieh ST. (2004). Pharyngeal-brachial palsy after cytomegalovirus colitis. Neurology 62:153-154 (highlight article)
Pan CL, Tseng TJ, Lin YH, Chiang MC, Lin WM, Hsieh ST. (2003). Cutaneous innervation in Guillain-Barré syndrome: pathology and clinical correlations. Brain 126:386-397. [link]
Chiang MC, Lin YH, Pan CL, Tseng TJ, Lin WM, Hsieh ST. (2002). Cutaneous innervation in chronic inflammatory demyelinating polyneuropathy. Neurology 59: 1094-1098. [link]
Pan CL, Yuki N, Koga M, Chiang MC, Hsieh ST. (2001). Acute sensory ataxic neuropathy associated with monospecific anti-GD1b IgG antibody. Neurology 57: 1316-1318. [link]
Pan CL, Lin YH, Lin WM, Tai TY, Hsieh ST. (2001). Degeneration of nociceptive nerve terminals in human peripheral neuropathy. Neuroreport 12: 787-792. [link]
Reviews, Commentaries and Methods Papers
Chen CK and Pan CL.* (2022) Cell polarity control by Wnt morphogens. Developmental Biology 487: 34-41.
Chen CH* and Pan CL.* (2021) Live-cell imaging of PVD dendrite growth cone in post-embryonic C. elegans. STAR Protocols 2: 100402 [link]
Wu YC, Chiang YC, Chou SH, Pan CL. (2021) Wnt signaling and endocytosis: mechanisms, controversies and implications for stress responses (invited review). Biol Cell 113: 95-106. doi:10.1111/boc.202000099 online ahead of print [link]
He CW, Liao CP, Pan CL. (2018) Wnt signaling in the development of axon, dendrites and synapses (invited review). Open Biology (Royal Society of UK) 8: 180116. [link]
Lin CT, He CW, Huang TT, Pan CL. (2017) Longevity control by the nervous system: sensory perception, stress response and beyond. (invited review) Transl. Med. Aging 1: 41-51 [link]
Chiang MC, Tseng MT, Pan CL, Chao CC, Hsieh ST. (2015). Progress in the treatment of small fiber peripheral neuropathy. Expert Rev. Neurother. 15: 305-313. [link]
Chen CH, Chen YC, Jiang HC, Chen CK, Pan CL. (2013). Neuronal aging: learning from C. elegans. (invited review) J. Mol. Signal. 8: 14 [link]
Peng CY, Chen CH, Hsu JM, Pan CL. (2011). C. elegans model of neuronal aging. Commun. Integr. Biol. 4: 696-698. [link]